Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
chloramphenicol palmitate
CAS: 530-43-8
Molecular Formula: C27H42Cl2N2O6
Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide - Names and Identifiers
Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide - Physico-chemical Properties
| Molecular Formula | C27H42Cl2N2O6 |
| Molar Mass | 561.54 |
| Density | 1.2354 (rough estimate) |
| Melting Point | 90 C |
| Boling Point | 691.6±55.0 °C(Predicted) |
| Specific Rotation(α) | D26 +24.6° (c = 5 in ethanol) |
| Flash Point | 372.1°C |
| Water Solubility | 8.423ug/L(25 ºC) |
| Solubility | DMSO (Slightly), Ethanol (Sparingly), Ethyl Acetate (Slightly) |
| Vapor Presure | 4.43E-20mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['271nm(EtOH)(lit.)'] |
| Merck | 14,2077 |
| BRN | 2826438 |
| pKa | 10.69±0.46(Predicted) |
| Storage Condition | Store at RT. |
| Stability | Hygroscopic |
| Refractive Index | 1.7350 (estimate) |
| Physical and Chemical Properties | White or yellowish powder crystals. The melting point of 90 deg C, very slightly soluble in water (28 deg C 1.05mg/ml). Soluble in methanol, ethanol, chloroform, ether, benzene. |
Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | RT4735000 |
| HS Code | 29414000 |
Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide - Upstream Downstream Industry
| Raw Materials | Benzene Thionyl chloride chloroamphenicol Palmitic acid |
Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide - Reference Information
| biological activity | Chloramphenicol palmitate is a broad-spectrum antibiotic (antibiotic) with oral activity, which has a wide range of activities against gram-positive and gram-negative bacteria. Chloramphenicol palmitate inhibit the protein synthesis of bacteria by blocking the synthesis of peptidyl transferase. Chloramphenicol palmitate can be used as a bacterial screening agent for transformed cells containing chloramphenicol resistance genes (bacterial selection agent). |
| use | antibiotics. |
| production method | add α-methylpyridine and benzene to the reaction pot, add chloramphenicol under stirring, keep at 32-37 ℃, and add palmitoyl chloride dropwise. After adding, continue stirring for 4 hours, add to 15 times of water, and precipitate crude products. The crude product is washed, decolorized and recrystallized to obtain tasteless chloramphenicol. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-mouse LD50: 2640 mg/kg |
| flammability hazard characteristics | thermal decomposition discharges toxic nitrogen oxides and chloride smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 21:01:54
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Raw Materials for Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide